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Inventi Impact: Molecular Pharmacology

Articles

  • Inventi:pmp/32030/20
    Autophagy Inhibition Potentiates the Anticancer Effects of a Bendamustine Derivative NL-101 in Acute T Lymphocytic Leukemia
    Research 2020 : July - September
    Hang Gao, Siyue Lou, Huanwu Hong, Qiufu Ge, Huajun Zhao

    Acute T lymphocytic leukemia (T-ALL) is an aggressive hematologic resulting from the malignant transformation of T-cell\nprogenitors. Drug resistance and relapse are major difficulties in the treatment of T-ALL. Here, we report the antitumor potency of\nNL-101, a compound that combines the nitrogen mustard group of bendamustine with the hydroxamic acid group of vorinostat.\nWe found NL-101 exhibited efficient antiproliferative activity in T-ALL cell lines (IC50 1.59â??1.89...............

    How to Cite this Article
    Attribution/ CC Compliant Citation: Gao, Hang, et al. \"Autophagy\nInhibition Potentiates the Anticancer Effects of a Bendamustine\nDerivative NL-101 in Acute T Lymphocytic Leukemia.\" BioMed\nResearch International 2020 (2020).\nhttps://doi.org/10.1155/2020/1520651\nhttp://creativecommons.org/licenses/by/4.0/\nSome formatting elements, header, footer, logos, dates and\npagination were modified while adapting this article.
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